Memphis '59 ES-335 Reissues no longer have the "window" (center block cutout).
Aesthetically the vintage Klusons of the two factories have different color tips as of now. The Nashville ones are more transparent, the Memphis are a little more opaque and yellowed.
The ear shapes are different.
Other than those two differences, I'd take a lot of what you hear on the internet about this topic with a grain of salt. People who've purchased these guitars over the last several years have spent a lot of money on their instruments, and Gibson guitars in particular are sold at the prices they are because of the marketing surrounding the guitars. For a long time Gibson wanted people to think Nashville-finished ES guitars were better than Memphis-finished ESes. Now they've switched that, and want you to think Memphis guitars are the premier ones.
I think the only way to find a good guitar you'll be sure to love is to play it.
It's important for people to be honest with themselves about what kind of Gibson customer they are. Are you more interested in buying a guitar, replacing the plastics/pickups/switch tips and then posting pictures to brag about all the extra money you blew on making a perfectly wonderful guitar better meet some imagined ideal, only to then flip the guitar once Gibson releases another model year with an even more "authentic" ear shape? If that's you spend the money on whichever Gibson is charging more for so that you can get the most enjoyment from posting your guitar porn on the interwebs. You're only going to play it for a few hours before you'll be on to lusting after some other new shiny thing so who cares?
If however you're buying the guitar to play it: none of this matters a bit. You just need to find one that speaks to you! Do you like the way the pickups sound? Is the neck comfortable for you? Do you find the guitar inspiring to play? If so then you can safely forget about everything else, buy the guitar!
There are many, many of stories of our guitar heroes finding a special guitar among a bunch of others serendipitously. Look at Nile Rodgers' Hitmaker. Or that red Les Paul Clapton got from George, or Johnny Marr's first red ES-355. I think the Edge even has a story about his Explorer, and he still plays it even after the headstock broke off!
Great guitars are coming from both places, and depending on where you're shopping/time of year/how long the guitar's been stored you might not get a perfect out of the box experience. One of my most treasured guitars (ES-359 made in Memphis) came to me sounding remarkably horrid! Totally dead! It certainly needed a bit of TLC, but now it sings wonderfully. My '56 Les Paul Reissue (made in Nashville) had a broken jack plate, wreaked of cigarettes and had dings on the back of the neck. That one required quite a bit of help but it's now near and dear to my heart (I usually buy used).
Sorry for the rambling, I think my point could've been made more simply: are you buying a trophy or an instrument? Only you can answer that honestly. There's no shame in enjoying collecting guitars, Gibson is certainly marketing their high end instruments to collectors more than players. I record my ES-359 but I don't think I'd ever gig it. It's too pretty/unique/valuable (due to the Pelham Blue color). The Les Paul already had some dings so I've been much more comfortable taking it out (I did buy a beater case that doesn't say "Gibson Custom" for it though so as not to attract attention).
Guitars are very individualized instruments. We all play differently, play different styles of music, have different aesthetic tastes, etc. Is it important to you that your binding is perfectly finished? What if there's a tiny bit of orange peel, will that annoy you to no end even if the guitar sings the sweetest songs? If so, you need to be prepared to excercise your retailers' return policy because you might not get a perfect guitar the first time. Then a few months or maybe a year later, your frets are going to start making cracks in your binding. Be prepared. You might not notice though if the GAS for that guitar has worn off and it now spends most of its time in its case under the bed or on a hanger on the wall. If you're playing it, you'll have broken it in and will be unlikely to care. Just depends on what kind of a buyer you are :-)