Well here goes. I have had some experience with this. I have a 1971 Gibson Heritage with a Rosewood saddle. Not long after I got it new in 1972 a luthier said it would sound much better if he routed out the saddle and inserted a bone saddle.
It really is nice. Still mellow with a laid back sound, but with some extra clarity.
Now, I have tried the Graph Tech replacement and I didn't like the sound. I have now put in a ceramic saddle (I was lucky to fine 3) one for the Heritage, one for the Paul McCartney Texan and one for the Gibson J160. The sound is much better than the Graph Tech for sure, more full. It is a little bright, but very even across the board, and it is a nice sound. My wooden saddle has cracked so I am getting one made and a bone insert put in like the original. This way I can change back and forth as my daily ear requirements require :-)) Some say to get rid of the adjustable bridge and the guitar will sound better, more open. Maybe so, but I like the advantage of adjusting the action easily whenever I want. Also, guitars are built with all components in mind. You change something that is irreversable and you are stuck with it, and you may Not like it. I changed the tuners on an Epiphone EJ200, from the Heavy Metal (In weight) Gold Grovers to the Light Tuners (In weight) with Keystone buttons and it changed the sound of the guitar, not as much bottom end. I guess the weight difference on the headstock made the difference. I am rambling a bit, but I just wanted to state that any change, will change your sound.